[TP-085]

The Assosication Between Bladder Cancer and Metabolic Syndrome

Emrah YAKUT
Niğde State Hospital

Transitional cell bladder cancer is the most common malignity of genitourinary system. Incidence rate is rising rapidly in underdeveloped countries which are suffering from exposure to carcinogenesis due to industrialization.
The purpose of this study is to identify the relationship between metabolic syndrome and components of metabolic syndrome with stage, grade and degree of bladder cancer, existence of CIS and number of recurrence.

This study includes 200 patients consist of 25 female and 175 male. 100 patients suffer from metabolic syndrome while the other 100 don’t. The average age was found 63±12. The average systolic blood pressure, diastolic blood pressure, waist circumference, BMI, fasting blood glucose, HDL, LDL, trigylceride, HbA1c was identified 127±10 mmHg, 82±8 mmHg, 97±10 cm, 25.5±2.3 kg/m2, 104±24 mg/dl, 47±9 mg/dl, 129±33 mg/dl, 163±64 mg/dl and %5.5±0.9 respectively. T stages of bladder cancer were determined as Ta in 24 patients, T1 in 135 patients and T2 in 41 patients. The grade of bladder cancer was stated as low grade in 125 patients and high grade in 75 patients. CIS was found positive in 58 patients.

In the analyze of 75 high grade bladder cancer patients it is identified that there are 54 (72%) patients older than 60 years old, 49 (65,3%) patients smoking more than 40 pack-year, 41 patients (54,7%) with cancer history in their family. There are 41 patients who were diagnosed at T2 stage. 26 (63,4%) of these 41 patients are older than 60 years old, 28 (68,3%) of them are smoking more than 40 pack-year and 23 (56,1%) of them have cancer history in their family. In the utilized logistic regression analysis; smoking habit of more than 40 pack-year (p=0,001) and being older than 60 years old (p=0,024) were determined as independent risk factors for bladder cancer stage; having cancer history in family (p=0,003) and smoking habit of more than 40 pack-year (p=0,012) were determined as independent risk factors for bladder cancer grade.

Metabolic syndrome wasn’t found correlated with bladder cancer in our study. However there is a need for larger studies with prolonged follow up time for examing this relationship.