[PS-108]Oturum adı: POSTER SESSION 2 | Oturum salonu: POSTER AREA | Oturum tarihi: 23 Ekim 2015 | Oturum saati: 14:00 - 19:00Düşük Doz Tadalafil Kullanımının Seminal Parametrelere EtkisiAhmet SalvarciAMAÇ: İnfertil erkeklerde düşük doz tadalafil tedavisinin seminal parametrelerine etkisine bakıldı YÖNTEM: 2013-2014 arasında infertilite nedeniyle başvuran 39 erkek hasta iki gruba ayrıldı.Grup-I (n=19) günlük düzenli düşük doz 5 mg tadalafil aldı.Grup-II (n=10) haftada 1 veya 2 kere 20 mg tadalafil kullandı. Hastaların Anemnez,fizik muayene, International Index of Erectil Fonction-5 ile tedavi öncesi ve sonrası sorgulanması yapıldı. Tedavi öncesi ve sonrası spermiogramlarına, FSH,LH,total testosteronuna bakıldı. Günlük 5 mg tadalafil 3 ay süre ile verildi. BULGULAR: Yaş ortalaması 32±6 idi. Ortalama 8±5 yıl evliydiler. İnfertile süreleri 9±5 yıl idi. 11 hasta önceden tek ve/veya bilateral varikoselektomi, 14 çifte ıntra uterin inseminasyon uygulanmıştı. Fizik muayenede 3 hastada tek taraflı atrofik testis (ortalam 2x2x3 cm) gözlenildi.Muayenede varikosel gözlenilmedi. IIEF-5 sorgulamada 21±3 hesaplandı. Ortalama FSH 9.5±4.1 mIU/ml, LH 5.4±2.1 mIU/ml total testosteron 322±26 ng/ml idi. Tedavi öncesi Grup-I (n=19) volüm 4.3±1.9, sayı 8±4 x106, total motilite % 3±2, anormal sperm %94±5. Grup-II (n=10) volüm 5.1±1.5, sayı 7.8±3 x106, total motilite % 6±3, anormal sperm %89±6 (WHO) ölçüldü.Tedavi sonrası Grup-I (n=19) volüm 5.1±1.2, sayı 9.1±3.6 x106, total motilite % 24±4, anormal sperm %81±4. Grup-II (n=10) volüm 4.1±1.5, sayı 8±2.7 x106, total motilite % 8±2, anormal sperm %88±8 (WHO) ölçüldü. Tedavi sırasında haftalık kullanımda 2 hastada tölere edilebilir baş ağrısı oldu. Grup-I (n=19) sperm motilitesinde düzelme Grup-II (n=10) ye göre istatiksel olarak anlamlı fark ölçülmüştür (p<0.05) (tablo-I) SONUÇ: Düşük doz tadalafil 3 aylık tedavisinde kontrol grubuna göre sperm motilisinde belirgin artma izlenilmiştir. Impact of Low-Dose Tadalafil in Seminal ParametersAhmet SalvarciOBJECTIVE: The impact of low-dose tadalafil treatment on seminal parameters was assessed in infertile men. METHODOLOGY: Thirty-nine male patients who consulted us due to infertility between 2013-2014 were divided into two groups. Group-I (n=19) received a regular daily low dose of 5 mg tadalafil. Group-II (n=10) used 20 mg tadalafil once or twice a week. The anamnesis, physical examination and International Index of Erectile Function-5 questionnaire was performed before and after the treatment. Pre-treatment and post-treatment spermiogram, FSH, LH and total testosterone was evaluated. Tadalafil was administered for a period of 3 months at a daily dose of 5 mg. FINDINGS: The mean age was 32±6 years. Their period of infertility was 9±5 years. Unilateral and/or bilateral varicocelectomy was previously performed in 11 patients, while intrauterine insemination was applied on 14 couples. Unilateral atrophic testicle (2x2x3 cm on average) was observed in 3 patients in the physical examination. No varicocele was observed in the examination. The IIEF-5 questionnaire was calculated as 21±3. The mean FSH was 9.5±4.1 mIU/ml, LH was 5.4±2.1 mIU/ml and the total testosterone was 322±26 ng/ml. Prior to the treatment, the volume was 4.3±1.9, the number was 8±4 x106, the total motility was 3±2% and the rate of abnormal sperms was 94%±5 in Group-I (n=19). The volume was measured as 5.1±1.5, the number was 7.8±3 x106, the total motility was 6%±3 and the rate of abnormal sperms was 89%±6 in Group-II (n=10) (WHO). Following the treatment, the volume was 5.1±1.2, the number was 9.1±3.6 x106, the total motility was 24%±4 and the rate of abnormal sperms was 81%±4 in Group-I (n=19). The volume was measured as 4.1±1.5, the number was 8±2.7 x106, the total motility was 8%±2 and the rate of abnormal sperms was 88%±8 in Group-II (n=10) (WHO). Two patients experienced tolerable headache in the weekly use during the treatment. A statistically significant difference was measured in the improvement in sperm motility in Group-I (n=19) compared to Group-II (n=10) (p<0.05) (Table-I) CONCLUSION: A significant increase was observed in sperm motility compared to the control group in the 3-month treatment with low-dose tadalafil. Tedavi Önce ve Sonrası Sonuçlar
Before-After treatment Results
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